MmpL3, Wag31 and PlrA are involved in coordinating polar growth with peptidoglycan metabolism and nutrient availability. Arejan, NH, Czapski, DR, Buonomo, JA, and Boutte, CC (2024) Journal of Bacteriology 10.1128/jb.00204-24
PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis. SY Quintanilla, NH Arejan, PB Patel, CC Boutte (2023). doi: 10.1371/journal.pone.0280336
Polar protein Wag31 both activates and inhibits cell wall metabolism at the poles and septum. NH Arejan, PB Patel, SY Quintanilla, AE Saleh, CC Boutte (2023). doi: 10.3389/fmicb.2022.1085918
Mycobacterial Serine/Threonine phosphatase PstP is phospho‐regulated and localized to mediate control of cell wall metabolism. F Shamma, EH Rego, CC Boutte (2022) Mol Microbiol, Jun 07;118, 47– 60. doi: 10.1111/mmi.14951
Arginine methylation helps SepIVA balance regulation of septation and elongation in Mycobacterium smegmatis. AH Freeman, KE Tembiwa, JR Brenner, MR Chase, SM Fortune, YS Morita, CC Boutte (2022). doi: 10.1111/mmi.15006
In Mycobacterium abscessus, the Stringent Factor Rel Regulates Metabolism but Is Not the Only (p)ppGpp Synthase. AC Hunt-Serracin, MI Kazi, JM Boll, CC Boutte (2022) Journal of Bacteriology. Feb 15;204(2) doi: 10.1128/JB.00434-21
Phosphorylation on PstP Regulates Cell Wall Metabolism and Antibiotic Tolerance in Mycobacterium smegmatis. F Shamma, K Papavinasasundaram, SY Quintanilla, A Bandekar, C Sassetti, CC Boutte (2021) Journal of Bacteriology. Jan 25;203(4) doi: 10.1128/JB.00563-20
Mycobacterium abscessus cells have altered antibiotic tolerance and surface glycolipids in Artificial Cystic Fibrosis Sputum Media. Hunt-Serracin AC, Parks BJ, Boll JM, Boutte, CC (2019) Antimicrob Agents Chemother. Apr 22; doi: 10.1128/AAC.02488-18
Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis. Wu KJ, Zhang J, Baranowski C, Leung V, Rego EH, Morita YS, Rubin EJ, Boutte CC (2018) Journal of Bacteriology. Feb 23;200(6) doi: 10.1128/JB.00649-17
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. MBio. 2017 Jan 17;8(1). pii: e02133-16. doi: 10.1128/mBio.02133-16.
A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. Elife. 2016 Jun 15;5. pii: e14590. doi: 10.7554/eLife.14590.
Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. PLoS Pathog. 2015 Jun 26;11(6):e1005010. doi: 10.1371/journal.ppat.1005010. eCollection 2015 Jun.
Bacterial lifestyle shapes stringent response activation. Boutte CC, Crosson S. Trends Microbiol. 2013 Apr;21(4):174-80. doi: 10.1016/j.tim.2013.01.002. Epub 2013 Feb 16. Review.
ppGpp and polyphosphate modulate cell cycle progression in Caulobacter crescentus. Boutte CC, Henry JT, Crosson S. J Bacteriol. 2012 Jan;194(1):28-35. doi: 10.1128/JB.05932-11. Epub 2011 Oct 21.
The complex logic of stringent response regulation in Caulobacter crescentus: starvation signalling in an oligotrophic environment. Boutte CC, Crosson S. Mol Microbiol. 2011 May;80(3):695-714. doi: 10.1111/j.1365-2958.2011.07602.x. Epub 2011 Mar 16.
Genetic and computational identification of a conserved bacterial metabolic module. Boutte CC, Srinivasan BS, Flannick JA, Novak AF, Martens AT, Batzoglou S, Viollier PH, Crosson S. PLoS Genet. 2008 Dec;4(12):e1000310. doi: 10.1371/journal.pgen.1000310. Epub 2008 Dec 19.
Two-component signaling systems and cell cycle control in Caulobacter crescentus. Purcell EB, Boutte CC, Crosson S. Adv Exp Med Biol. 2008;631:122-30. doi: 10.1007/978-0-387-78885-2_8. Review.
PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis. SY Quintanilla, NH Arejan, PB Patel, CC Boutte (2023). doi: 10.1371/journal.pone.0280336
Polar protein Wag31 both activates and inhibits cell wall metabolism at the poles and septum. NH Arejan, PB Patel, SY Quintanilla, AE Saleh, CC Boutte (2023). doi: 10.3389/fmicb.2022.1085918
Mycobacterial Serine/Threonine phosphatase PstP is phospho‐regulated and localized to mediate control of cell wall metabolism. F Shamma, EH Rego, CC Boutte (2022) Mol Microbiol, Jun 07;118, 47– 60. doi: 10.1111/mmi.14951
Arginine methylation helps SepIVA balance regulation of septation and elongation in Mycobacterium smegmatis. AH Freeman, KE Tembiwa, JR Brenner, MR Chase, SM Fortune, YS Morita, CC Boutte (2022). doi: 10.1111/mmi.15006
In Mycobacterium abscessus, the Stringent Factor Rel Regulates Metabolism but Is Not the Only (p)ppGpp Synthase. AC Hunt-Serracin, MI Kazi, JM Boll, CC Boutte (2022) Journal of Bacteriology. Feb 15;204(2) doi: 10.1128/JB.00434-21
Phosphorylation on PstP Regulates Cell Wall Metabolism and Antibiotic Tolerance in Mycobacterium smegmatis. F Shamma, K Papavinasasundaram, SY Quintanilla, A Bandekar, C Sassetti, CC Boutte (2021) Journal of Bacteriology. Jan 25;203(4) doi: 10.1128/JB.00563-20
Mycobacterium abscessus cells have altered antibiotic tolerance and surface glycolipids in Artificial Cystic Fibrosis Sputum Media. Hunt-Serracin AC, Parks BJ, Boll JM, Boutte, CC (2019) Antimicrob Agents Chemother. Apr 22; doi: 10.1128/AAC.02488-18
Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis. Wu KJ, Zhang J, Baranowski C, Leung V, Rego EH, Morita YS, Rubin EJ, Boutte CC (2018) Journal of Bacteriology. Feb 23;200(6) doi: 10.1128/JB.00649-17
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. MBio. 2017 Jan 17;8(1). pii: e02133-16. doi: 10.1128/mBio.02133-16.
A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. Elife. 2016 Jun 15;5. pii: e14590. doi: 10.7554/eLife.14590.
Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. PLoS Pathog. 2015 Jun 26;11(6):e1005010. doi: 10.1371/journal.ppat.1005010. eCollection 2015 Jun.
Bacterial lifestyle shapes stringent response activation. Boutte CC, Crosson S. Trends Microbiol. 2013 Apr;21(4):174-80. doi: 10.1016/j.tim.2013.01.002. Epub 2013 Feb 16. Review.
ppGpp and polyphosphate modulate cell cycle progression in Caulobacter crescentus. Boutte CC, Henry JT, Crosson S. J Bacteriol. 2012 Jan;194(1):28-35. doi: 10.1128/JB.05932-11. Epub 2011 Oct 21.
The complex logic of stringent response regulation in Caulobacter crescentus: starvation signalling in an oligotrophic environment. Boutte CC, Crosson S. Mol Microbiol. 2011 May;80(3):695-714. doi: 10.1111/j.1365-2958.2011.07602.x. Epub 2011 Mar 16.
Genetic and computational identification of a conserved bacterial metabolic module. Boutte CC, Srinivasan BS, Flannick JA, Novak AF, Martens AT, Batzoglou S, Viollier PH, Crosson S. PLoS Genet. 2008 Dec;4(12):e1000310. doi: 10.1371/journal.pgen.1000310. Epub 2008 Dec 19.
Two-component signaling systems and cell cycle control in Caulobacter crescentus. Purcell EB, Boutte CC, Crosson S. Adv Exp Med Biol. 2008;631:122-30. doi: 10.1007/978-0-387-78885-2_8. Review.
